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Is Ketamine Natural?

A 2020 study in Parasites & Vectors found that the fungus Pochonia chlamydosporia is a natural source of ketamine. The isolated compounds evidenced nematicidal activity. Upon separation and purification of the isolates liberated from P. chlamydosporia, ketamine was revealed as a major constituent. We intend to research this claim further and prove whether or not Ketamine is naturally occurring.
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You may have heard of the recent excitement around ketamine. First synthesized in 1962 by Calvin L Stevens, ketamine is a schedule III Non-Nacotic first approved for use in 1970 as a dissociative anesthetic used in surgery for both human and veterinary medicine.

However, ketamine has seen a resurgence in popularity after discovering its potential as a therapy for pain and treatment resistant depression in 2000. Popular for its safety profile when compared to CNS depressants like opiates, this discovery has been described as “the single most important advance in the treatment of depression in more than 50 years”. Fast Forward 20 years and we’re now seeing ketamine clinics springing up across the globe offering safe and convenient walk-in/out-patient treatments for people with previously untreatable depression and pain.

Even more remarkable, a recent report shocked the psychedelic world: Long considered a human invention, ketamine has been isolated in a fungus known as Pochonia chlamydosporia.

Pochonia chlamydosporia is a microscopic fungus being studied as a biopesticide for nematodes (also known as roundworms). These fungi deploy ketamine as an anthelmintic defense system (helminths are a class of small parasitic worms that eat fungus like Pochonia). Biochemical warfare at the microscopic level.

Finding ketamine in natural organisms like P. chlamydosporia broadens the research potential for ketamine. So Noonautics has endeavored to kickstart research to verify one of the decade’s most exciting “new” discoveries.



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